We're excited to share a major step forward: the nCounter® platform is now enabling simplified RNA and protein analysis in a single workflow. Dive into our newest capabilities for bulk multiomics, get to know CosMx® SMI 2.0, and explore recent studies, how-to resources, and upcoming events. Whether you’re advancing discovery or streamlining validation, there’s something here to power your next breakthrough.
What's New
Big Announcement: The nCounter platform is evolving beyond gene expression!
Multiomics made simple!
Same sample. Same platform. Same run. Explore simplified multiomics with RNA and protein analysis from the same sample.
nCounter Bulk Multiomics Highlights
- Rapid sample to answer: Get multiomic results in 3 days with one platform and minimal hands-on-time.
- Challenging sample compatibility: As with the original nCounter workflow, the multiomics technology can utilize whole slide FFPE and fresh frozen samples.
- Modular panels: Stackable protein panels can be combined with your favorite nCounter RNA panels to create the customized assay you need.
- Simplified data analysis: Jointly or independently assess RNA and protein data.
Introducing CosMx SMI 2.0
CosMx SMI 2.0 is an integrated software upgrade that will enable the CosMx Whole Transcriptome (WTX) Assay, deliver up to 2X higher RNA sensitivity for all commercial RNA panels, and introduce the latest generation of best-in-class accurate cell segmentation.
Interested in learning more? Watch our webinar introducing CosMx 2.0, which also contains an introduction to the CosMx Whole Transcriptome Assay.
Galaxy Spatial World Tour
The first wave of the Galaxy Spatial Tour has concluded! We've engaged with spatial researchers in over 15 different cities across the world and are just getting started! Throughout each session we discussed best practices, listened to esteemed investigators share their experiences, and looked toward the future of meaningful insights from spatial transcriptomic and proteomic data to solve real spatial problems.
We are thrilled to be back on the road soon! Stay tuned for an event coming to a city near you.
Special Promotion on nCounter Services
For a limited time, take advantage of discounted pricing on our nCounter targeted gene expression services with Canopy Multiomic Services. Get high quality data with quick turnaround, now at a lower cost.
Available only in North America.
Resource Spotlight
CellScape 101 Now Available on NanoU
Just getting started with CellScape™ Precise Spatial Proteomics? Or need a quick refresher? CellScape 101 is now live on NanoU, packed with essentials to get you up and running fast:
- Step-by-step sample prep for FFPE and fresh frozen tissue
- How cyclic immunofluorescence and EpicIF™ technology drive high-plex assays
- Tips for building panels using 6,000+ compatible antibodies
- Explore ready-to-run VistaPlex™ kits and real dataset examples
New CosMx SMI Tips
Take a read of our most recent blog post in our CosMx SMI Best Practices series of posts to learn two tips to optimize sample prep for highly autofluorescent samples.
- Tip 1: Chemical bleaching during sample preparation
- Tip 2: Benchtop photobleaching during slide preparation
Fast Intro to nCounter Targeted Gene Expression Analysis
If you're new to nCounter targeted gene expression analysis check out Technology Network's latest "Teach Me in 10" video. In just 10 minutes you will learn how to expedite your validation and screening studies with robust targeted gene expression tools.
Watch the episode to uncover answers to the following:
- Why is targeted gene expression analysis for validation and screening so advantageous?
- What are some differentiating nCounter system advantages (i.e. proven correlation with sequencing, direct transcript detection, a rapid sample-to-answer workflow and robust 800-plex panels)?
- When is it better to do targeted gene expression analysis?
- How is nCounter evolving into a multiomics platform?
Optimize Your Spatial Proteomic Assays with the CellScape Platform
Designing multiplex immunofluorescence assays just got even easier! Our latest technical article guides you through building custom panels, choosing fluorophores for maximum multiplexing, and fine-tuning assays for consistent performance on the CellScape platform.
What You'll Learn:
- Smart antibody and fluorophore selection to boost assay performance
- How to achieve precise cell segmentation with DNA staining
- Tips to reduce autofluorescence and enhance signal clarity
- Strategies for iterative assay optimization and panel expansion
Ready to take your spatial proteomics to the next level?
GeoMx DSP Illuminates Subtypes in iCCA
A new study published in OncoImmunology showcases how GeoMx® Digital Spatial Profiling (DSP) and high-plex protein panels were used to deeply characterize the tumor-immune landscape of intrahepatic cholangiocarcinoma (iCCA), a highly aggressive and understudied form of liver cancer.
Publication Highlights
- Biology-driven profiling: Protein panels profiled tumor and immune niches and enabled spatial profiling from small, clinically relevant iCCA tissue samples
- Five immune subtypes revealed: Each linked to distinct prognostic outcomes
- Biology-driven profiling: Supports immune-based classification and future prognostic tools
ICYMI (In Case You Missed It)
Available NOW: CosMx Human Whole Transcriptome (WTX)
Reveal complete biology with subcellular whole transcriptome imaging for uncharted discoveries. With coverage of ~19,000 RNA targets and broad sample compatibility, request your quote for the CosMx Human Whole Transcriptome Assay and get started right away!
Bruker Spatial Biology Pharma & CRO Summit
It's not too late: On-demand viewing is now available.
Discover how our solutions are accelerating drug discovery and development across industry and academia.
Session Highlights:
- Discovering novel biomarkers and drug targets with GeoMx DSP spatial discovery multiomics
- Identifying disease mechanisms using insights from high-fidelity, subcellular spatial imaging with CosMx SMI
- Revealing target behavior with custom assays powered by CellScape Precise Spatial Proteomics
- Characterizing novel ADCs using the nCounter platform's robust and rapid targeted gene expression analysis
Spatial Biology Took Center Stage at AACR 2025
Thanks to everyone who stopped by the booth or attended our Exhibitor Spotlight at AACR 2025. Your dedication to advancing cancer research continues to inspire us all. From groundbreaking discussions to meaningful connections, it was an unforgettable experience. Until next time- let’s keep pushing boundaries and making a difference!
In case you missed it, check out our posters and a re-air of our Exhibitor Spotlight.
At Bruker Spatial Biology, we are dedicated to advancing science through innovation, collaboration, and unmatched flexibility. Follow along for more updates, resources, and opportunities to transform your research.