Take Your Immunology Research Further
Our nCounter services enable you to characterize immune status, understand immune response and study the progression of infection using one of the panels in the immunology and infectious disease portfolio. Choose one of these high-plex panels relevant to your study to analyze differential gene expression and pathway data, enabling you to make discoveries impacting human health.
For research in immuno-oncology, CAR-T cell therapy, infectious disease and drug development, this panel is a multifaceted tool. Uncover the mechanisms behind T cell, B cell, and NK cell exhaustion in diverse contexts, including cancer, with this 785 gene immunology panel. Characterize immune status, develop signatures for assessing the exhausted state and identify novel therapeutic targets to prevent or reverse exhaustion.
Quantify the expression of hundreds of genes involved in core metabolic processes and signaling pathways in the context of cancer and immunity. The underlying molecular mechanisms behind alterations in metabolic pathways, signaling pathways, and cell stress can be explored with this 748 gene panel, giving researchers a complementary tool to traditional metabolite assays for profiling metabolic checkpoints and discovering potential therapeutic targets.
Identify biomarkers for rejection, uncover mechanisms of tissue damage, and study toxicities brought on by immunosuppressive drugs with the Human Organ Transplant panel. Comprehensively profile the immune response to transplanted tissue with this 770 gene target panel, targeting 37 pathways. Develop signatures for rejection pre- and post-transplant to better understand and improve transplant efficiency.
This 770 gene immunology panel is designed to enable researchers to discover links between known autoimmune disease associated germline variants and their gene expression. Covering the top nine autoimmune diseases, it is ideal to explore disease associated mutation gene functionality and biomarker characterization.
Assess host immune response in human or mouse and track transcriptional profiles with the Immunology panel. Multiplex gene expression analysis with over 500 immunology genes including major classes of cytokines and their receptors, enzymes with specific gene families, interferons and their receptors, the TNF-receptor superfamily, and the KIR family genes.
Non-human primate (NHP) research is critical to provide insight into the functionality of drugs and vaccines in development. However, these studies are costly so getting maximum biological information out of each sample in a cost-effective and robust manner is crucial. This panel includes 770 gene targets key to immune responses and immune-related signaling pathways.
This 770 gene immunology panel is designed to encompass all aspects of myeloid innate immune response for use in basic and translational studies. It uses quantitative and qualitative measurements of attributes of innate immune response by evaluating enrichment of genes involved in recruitment and activation of myeloid subtypes.
Study the phases and progression of infection across the five major components of the host response with pathogen-agnostic targets. Profile 785 human genes across 50+ pathways, develop gene expression signatures of immune response, and validate biomarkers for disease severity.
This 770 gene immunology panel is designed to study chronic inflammatory diseases, immune-related adverse effects, and autoimmune diseases. Focusing on 35 pathways and processes, it enables evaluation of immune system dysfunction and the study of mechanisms of action. It covers both adaptive and innate immune responses involved in the most common autoimmune diseases.
Healthy adaptive immune systems are characterized by a diverse population of T cell Receptors (TCRs). The introduction of a pathogen, cancer or transplanted organ can shift TCR diversity. The 129 genes on this panel identify indicators of disease onset and progression, response/non-response to treatment or recovery.
Explore expression of 250 genes focused on inflammation in general immunology research including allergy, autoimmune diseases, and infectious disease immune response. The genes included cover a broad range of relevant pathways related to inflammation including apoptosis, EGF, interleukin signaling, Ras, T cell receptor and toll-like receptor signaling.
Uncover the mechanisms of disease pathogenesis, identify biomarkers of progression, and develop signatures for therapeutic response. Profile expression of 770 genes across 51 annotated pathways involved in the 4 stages of fibrosis: initial tissue damage response, chronic inflammation, proliferation of fibrotic cells, and tissue modification leading to fibrotic disease of the lungs, heart, liver, kidney, and skin.
Access Clinically-Relevant Gene Expression Signatures
We are one of only five nCounter service providers that offer nAlgorithm™ gene signature reporting for biopharma clinical studies. We offer the Tumor Inflammation Signature (TIS), Lymphoma Subtyping Test (LST), and PAM50 assays. These signatures provide cell typing and quantification, assist in patient stratification, and facilitate better biomarker identification.
A Turnkey Solution for Gene Expression Analysis
Our nCounter service is streamlined and efficient, with three simple steps to deliver reproducible data for your study.
Select Your Gene Panel
Choose from one of the predesigned gene panels relevant to your research, customize it with a spike in, or design your own.
Tell Us About Your Samples
Provide the sample number, sample type and species, and we will take care of the rest. We can also isolate RNA from your blood, cell pellets, or tissue samples.
We Deliver Your Data
We include raw and normalized data in your nCounter service. We also offer a premium data analysis packages through ROSALIND for differential gene expression analysis.
Access Extensive Immune Profiling for Any Sample Type
Leverage our CellScape™ Precise Spatial Proteomics platform to perform deep, highly multiplexed immune profiling on either suspension cells or tissue samples. Flexible and customizable for your unique research needs, our CellScape Service includes your choice of our modular immune profiling panels, your preferred markers, or both.
In addition to analyzing your quantitative cell phenotyping data, we offer high-throughput transcriptomics technologies to complement your proteomic insights. Our comprehensive suite of immunology services includes single-cell RNA-seq, GeoMx® digital spatial profiling, and CosMx™ spatial molecular imaging, together providing a complete view of immunological responses.
Additional nCounter Panels
Oncology
The Oncology Panels are curated, high-plex collections selected for cancer research, ranging from multiple pan-cancer panels to more focused panels supporting CAR-T and ADC development.
Specialized Applications
The Specialized Application Panels support a range of focused research topics including cardiovascular disease, neuroscience, stem cell technologies, microRNA, and gene therapies.
Frequently Asked Questions
Yes - if you choose to analyze your data through ROSALIND, we will provide comprehensive training upon data delivery to help you confidently analyze your data. As the expert in your samples and study, we encourage you to lead the analysis. While we can help support you, we don't provide it as a service outside of our partner ROSALIND. To learn more about how we can help, contact us.
nCounter is a powerful technique for gene expression profiling and highly successful and reproducible in most sample types including formalin-fixed paraffin-embedded (FFPE) tissue, crude cell lysates and blood. We can do the RNA isolation for you, or you can send us your purified total RNA.