AGBT 2025 was a whirlwind of innovation and excitement. Our Morning Buzz sessions provided deep dives into the latest in spatial biology each day, while our Brews with Bruker gathering served up lively conversation over craft brews. We also hosted a Silver Sponsor Workshop, where our spatial experts shared the recent developments across our Bruker Spatial Biology platforms. Whether you joined us in person or are catching up from afar, this newsletter is packed with new developments, resources, and opportunities in spatial biology. Let’s dive in!
What's New
New Product Announcements at AGBT
Last month, we made several exciting product announcements at AGBT. Here is a quick rundown of the new products we are preparing to release:
- PaintScape™ 3D Genome Visualization – Direct in situ 3D genome visualization
- CosMx® Whole Transcriptome Panel (WTX) – Unprecedented spatial resolution at the whole transcriptome scale enabling a paradigm-shifting pathways-first view of biology
- GeoMx® Discovery Proteome Atlas (DPA): 1K Protein Panel – The highest-plex multiomics solution for unparalleled insights
- CellScape's PowerOMX™ Data Engine – Transforming spatial data into discovery
Early access to PaintScape will be available Summer, 2025. The CosMx WTX and GeoMx DPA panels will begin shipping this summer also. CellScape instruments with PowerOMX will begin shipping immediately, and installed instruments are eligible for upgrades.
Scientific Spotlight at AGBT
Dr. Parambir Dulai from Northwestern University School of Medicine shared how he leverages spatial biology in IBD research, demonstrating the advantages of CosMx single-cell Whole Transcriptome analysis over other spatial platforms and scRNA-seq with real-world data.
If you missed AGBT, you can still catch all the updates, including Dr. Dulai’s presentation! Watch our AGBT workshop on demand.
Resource Spotlight
Spatial Multiomics Reveals Clues about Alzheimer's Disease
Dr. Miranda Orr and her team leverage advanced spatial multiomics, combining regional discovery with subcellular proteomic imaging, to uncover new Alzheimer’s disease markers:
- The GeoMx Digital Spatial Profiler with the new DPA panel was used for large-scale transcriptomic and proteomic profiling
- The CellScape™ Precise Spatial Proteomics platform enabled biomarker mapping and validation by high-resolution imaging
This integrated approach supports a research pipeline from discovery to translation and enables earlier detection of disease processes and supports the development of targeted, more effective treatments for Alzheimer’s disease. Explore how spatial multiomics supports neuroscience research in our latest blog.
CosMx WTX Enables Detection of Extremely Rare Cells in Pancreas
In our poster, “Spatially resolved whole transcriptomics: A paradigm shift for tissue analysis,” presented at AGBT 2025, we benchmarked the CosMx Whole Transcriptome (WTX) panel against a leading droplet-based single-cell analysis technology (scRNA-seq). Key findings included:
- Unbiased Coverage: WTX demonstrated equal or better detection efficiency than scRNA-seq across 7 cell types in colon cancer, with superior detection of irregularly shaped cell types.
- Detection of Rare Cells: WTX identified extremely rare Epsilon cells from pancreas tissue, while the lower-throughput scRNA-seq workflow did not.
Confidence in Every Biomarker
Achieving reliable spatial biology data starts with confidence in your assay. VistaPlex™ Assay Kits for the CellScape platform are developed with a rigorous selection and validation process to ensure specificity and sensitivity across diverse sample types. Each panel is also validated across multiple instruments and lab sites to confirm reproducibility.
Get high-quality results without time-consuming assay development: discover the science behind our validation process.
ICYMI (In Case You Missed It)
Watch On Demand: Bruker Brain Day 2025
Missed our Bruker Brain Day webinar? No problem- it is now available on demand for immediate viewing.
Learn more about:
- Discovering Novel Biomarkers: Learn about the identification of new biomarkers for cerebral Small Vessel Disease (cSVD) with the nCounter® Analysis Platform.
- Exploring Microglial Function: Hear about the mapping of microglial morphology and function in ischemic stroke recovery with the CosMx Neuroscience Protein Panel.
- Integrating Multiomic Data: Gain insights into high-plex single-cell spatial molecular imaging with CosMx SMI for comprehensive neural analysis.
Live from the Amsterdam CX Lab: Bruker Spatial Biology Solutions
Watch the latest edition of our Live from the Customer Experience Lab series to hear about the complete Bruker Spatial Biology portfolio. Explore tissues like never before with our comprehensive suite of technologies for targeted gene expression analysis, spatial transcriptomics, spatial proteomics, and spatial multiomics. Discover how to access these cutting-edge tools at our Customer Experience Lab in Amsterdam by watching now.
STAMP: Single-cell Transcriptomics Analysis and Multimodal Profiling through Imaging
Learn how this groundbreaking approach enables ultra-high-throughput RNA and protein profiling without sequencing costs. Using CosMx SMI, researchers from CNAG, Spain applied STAMP to analyze millions of cells, combining RNA and protein profiling for deep insights into cellular function.
Decoding neuroinflammation in Amyotropic Lateral Sclerosis / Motor Neurone Disease (ALS/MND)
Hear from University of Sheffield researchers on how they applied the nCounter NeuroInflammation panel to ALS/MND research, comparing findings with archival data. PLUS, discover the future of multiomics with the nCounter platform! Get a first-hand look at our streamlined workflow featuring harmonized pathway annotations for RNA and Protein.
At Bruker Spatial Biology, we are dedicated to advancing science through innovation, collaboration, and unmatched flexibility. Follow along for more updates, resources, and opportunities to transform your research.