December 2024 Newsletter

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We’re excited to bring you the latest updates, innovations, and resources in spatial biology. From cutting-edge technologies to global milestones, here’s what’s new in the world of Bruker Spatial Biology. Discover groundbreaking innovations like EpicIF™ technology and the Human 6K Discovery Panel, designed to transform multiomics research. Explore recent publications, tips, and more as we advance spatial biology with unmatched solutions and insights.

Product Updates

EpicIF Technology: Unmatched Flexibility in Spatial Biology

Multicolor microscopy of human tonsil tissue
FFPE tonsil, captured on the CellScape Platform with EpicIF Technology.

We recently unveiled a breakthrough update to our CellScape™ Precise Spatial Proteomics platform—introducing the revolutionary EpicIF technology. Building on our trusted filtered photobleaching workflow, this advanced solution delivers:

  • Gentle yet powerful signal removal to preserve delicate tissue samples.
  • Compatibility with nearly any fluorophore, ensuring seamless multiplex tissue imaging.
  • Truly high-plex spatial biology capabilities without compromise.

EpicIF technology is set to redefine multiplex imaging, enabling researchers to gain deeper insights into tissue architecture and protein expression like never before.

New CosMx® SMI Human 6K Discovery Panel dataset

Spatially resolved cell type map of entire lymph node tissue section.
Spatially resolved cell type map of entire lymph node tissue section.

See over 6,000 targets with our newest 6,000+ dataset release.

  • Move beyond individual gene analysis to understand functional, biological pathways at single-cell resolution.
  • CosMx 6K Discovery panel provides coverage for 6175 RNA targets, including 3350+ ligand-receptor pairs and 1595+ reactome pathways. This level of coverage enables scientists to project the reactome pathways direct onto tissue and maximize the amount of biology you discover.

Resource Spotlight

Analyzing CosMx SMI Data: A Researcher’s Perspective

Join Helena Lucia Crowell , bioinformatician at the Holger Heyn Lab (CNAG), as she shares her firsthand experience analyzing CosMx SMI Whole Transcriptome data for tubulovillous adenomas and learn how CosMx empowers researchers to uncover molecular insights with unprecedented spatial resolution.

Publications

First pre-print showing detection of whole transcriptome on CosMx SMI

Read our recent work showcasing sub-cellular imaging of the entire protein-coding human transcriptome!

  • Targeting 18,933 RNAs, our breakthrough Whole Transcriptome (WTX) panel can explore human FFPE tissue sections without dissociation or amplification.
  • Analyzing 5.4 billion transcripts across 2.7 million cells in 6 human tissue types, the WTX panel achieved exceptional accuracy and comprehensive transcriptome coverage. There is so much to discover with spatial whole transcriptomics!
CosMx pre-print

New GeoMx DSP Discovery Multiomics preprint

Read our new Discovery Multiomics preprint, where Tan et al. (npj Precision Oncology) highlights GeoMx Whole Transcriptome Atlas (WTA) and GeoMx IO Proteome Atlas (IPA) for serial section analysis of mucosal HNSCC for biomarker discovery. The team of researchers at The University of Queensland developed a high-plex spatial proteomic methodology for the characterization of the head and neck tumour microenvironment.

  • Using the GeoMx DSP researchers identified both proteomic and transcriptomic spatial signatures associated with improved outcomes.
  • Get a deeper understanding of complex biological processes by profiling the entire Transcriptome plus 570+ proteins with GeoMx DSP. Bruker Spatial Biology offers the only same-slide discovery multiomics technology in labs today. Profile meaningful regions to minimize noise and simplify your analysis and gain integrated insight with a single section using GeoMx DSP.
A venn diagram showing shared and unique genes identified by GeoMx IPA and GeoMx WTA assays in tumor.
Venn diagram showing shared and unique genes identified by GeoMx IPA and GeoMx WTA assays in tumor and stromal regions, grouped by overall survival (OS) and disease-free survival (DFS). Common genes for each region are highlighted.

New CosMx Publication Makes the Cover of Science Translational Medicine

Read the recent publication featuring CosMx SMI technology, which made the cover of Science Translational Medicine Magazine. Kudos to the team, including scientists from the University of Washington, the University of Colorado, and our very own Patrick Danaher.

The study analyzed tissue from patients with cLN pathology, which could help in developing more personalized therapies for this disease.

CosMx Translational Medicine Cover

Bruker Spatial Biology Around the World

Global Milestones and Exciting Updates

  • CosMx Spatial Molecular Imager is now back in Germany, opening doors for groundbreaking research and discoveries across Europe.
  • The first-ever GeoMx DSP in Latin America has been installed at Instituto D'Or de Pesquisae Ensino (IDOR) through our valued partners at Uniscience do Brasil.

We’re thrilled to see how these milestones will shape the future of spatial biology in their regions.

Bruker Spatial Biology at MultiOmics 2024 in Brisbane

Joe Beechem and Oliver Braubach presented at MultiOmics 2024. A key conference among spatial biology leaders, where we showcased how Bruker Spatial Biology is shaping the future of spatial multiomics.

multi-omics

Other conferences Bruker Spatial Biology attended were Spatial Bio West and San Antonio Breast Cancer Symposium.

Tips, Tricks, and Resources

New eBook: Unlock Gene Expression Tools for Drug Development

Are you looking for tools to expedite your drug development pipeline? Look no further. Our newly released eBook explores the unparalleled benefits of nCounter technology, offering insights into:

  • Strategic applications across all stages of drug development.
  • A powerful case study showcasing the combination of nCounter gene expression analysis and GeoMx profiling to uncover hidden biomarkers in early lung cancer.

This comprehensive guide demonstrates how nCounter technology can streamline your research and accelerate your journey from discovery to therapeutic breakthroughs.

FAQs Unleashed: Navigating GeoMx & nCounter Assays

Dive into answers to your top questions about GeoMx and nCounter workflows, functionality, and applications. This webinar offers invaluable tips for experiment planning and execution, demonstrating how these two technologies complement one another to drive impactful discoveries.

Watch our recent webinar to see what the GeoMx DSP can do for your multiomics research! Learn how Discovery Multiomics on GeoMx DSP is redefining spatial biology with integrated insights of health and disease from tissue samples.

Catch up on recent webinars packed with expert insights, tips, and best practices.

In Case You Missed It

SITC 2024

SITC 2024

It was a pleasure meeting and celebrating with everyone at SITC 2024 to mark the formation of Bruker Spatial Biology. Bringing together the forces of NanoString and Canopy Biosciences, we now offer the most comprehensive range of best-in-class solutions for multiomic research.

Spatial Proteomics Method of the Year

Nature Methods has named Spatial Proteomics its Method of the Year, highlighting this transformative approach as essential for advancing biological insights. We’re proud to lead the charge with our CellScape Precise Spatial Proteomics platform.

Nature Methods

Upcoming Events

AGBT General Meeting

Bruker Spatial Biology is proud to be a Silver Sponsor! Be sure to stop by our suite (Osprey 10) and attend our talk on Wednesday, February 26th where we have several exciting updates to reveal!

At Bruker Spatial Biology, we are dedicated to advancing science through innovation, collaboration, and unmatched flexibility. Follow along for more updates, resources, and opportunities to transform your research.

It's been an exciting year, stay tuned for our next Newsletter and see what we have in store for 2025.