With AGBT 2025 right around the corner and exciting announcements from Bruker Spatial Biology coming, we’re here to bring you the latest updates, innovations, and resources in spatial biology.
Upcoming Events
AGBT General Meeting
Bruker Spatial Biology is proud to be a Silver Sponsor of the Advances in Genome Biology and Technology (AGBT) General Meeting, a premier event taking place on February 23-26, 2025 that brings together global leaders, researchers, and innovators in genomics. Be sure to check back regularly as we get closer to the event.
Featured Events
Silver Sponsor Workshop
Attend our workshop and dive deeper into our best-in-class solutions for Spatial Biology research. This workshop will cover our major new product announcements, showcase innovations and discuss customer data in real time.
Date & Time: Wednesday, February 26, 12:15-1:15 PM
Location: Calusa Ballroom
In Program Presentation
Featured Talk
Join us for a pivotal talk by Joe Beechem, PhD, Chief Scientific Officer and SVP of R&D at Bruker Spatial Biology, on sub-cellular, multiomic imaging of the entire protein-coding transcriptome (18936-plex RNA) and 75-plex Protein on a single-slide FFPE tissue section using CosMx Spatial Molecular Imaging (SMI). Dr. Beechem will showcase how this cutting-edge innovation is reshaping the future of spatial biology.
Speaker: Joe Beechem, PhD, Chief Scientific Officer and SVP of R&D
Date & Time: Tuesday, February 25, 8:50-9:10 PM
Location: Calusa Ballroom
Product Updates
CosMx® SMI: Leading in Single-Cell Spatial Sensitivity
Sensitivity is critical in single cell spatial biology to enable high plex applications. In this video, Chief Scientific Officer Joe Beechem discusses the critical importance of sensitivity in single-cell spatial biology. From the outset, the design of CosMx® SMI aimed to exceed scRNA-Seq level capabilities with spatial context and sub-cellular resolution. What does sensitivity mean in Single-Cell Spatial Biology?
- Maximum number of transcripts per cell
- Largest diversity of transcripts per cell
- Performance in FFPE
CosMx SMI delivers on both sensitivity parameters, offering the highest plex capability in single-cell spatial analysis and high sensitivity for up to 6,000 genes, with whole transcriptome analysis coming soon. This is achieved using non-destructive methods on FFPE samples, preserving spatial context without any loss of cell numbers or bias in cell types. See the data in Dr. Beechem's presentation.
nCounter® Analysis Platform: New Year, New Insights
Start the year off right by looking to the future with nCounter Pro, the trusted platform for targeted gene expression. This third-generation instrument features modernized software and hardware upgrades to continue the high-performance reputation relied upon by translational researchers worldwide. See how the trend toward targeted gene expression can help your research with thematic panels for all major research areas, peer reviewed publications and a menu of applications to make your research a success in 2025.
Take advantage of savings when you upgrade your current nCounter system to the new nCounter Pro!
Resource Spotlight
Webinar On-Demand:
CellScape™ Precise Spatial Proteomics: From EpicIF to Navinci’s in situ Proximity Ligation Technology
Watch our recent insightful webinar with Navinci on utilizing the CellScape platform to pair multiplexed immunofluorescence with in situ PLA technology for powerful spatial proteomics and single-cell analysis. Combining multiplexed immunofluorescence with in situ PLA on the CellScape platform enhances spatial proteomics and single-cell analysis by allowing you to visualize multiple proteins and their interactions within their native tissue environment. This approach provides deeper insights into protein function, protein-protein interactions, and cellular heterogeneity, all at high resolution.
Webinar On-Demand
Bruker Spatial Biology: Exploring Tissues with Spatial Discovery and Targeted Gene Expression Analysis
Date & Time: January 28th, 11AM EST / 8AM PST
Explore tissues like never before with our comprehensive suite of technologies for targeted gene expression analysis, spatial transcriptomics, proteomics, and multiomics in our upcoming webinar where we’ll feature talks on the latest innovations to our nCounter, CosMx, GeoMx, and CellScape platforms.
Discover best-in-class solutions for your unique spatial research needs. Register today to learn more.
Cover-worthy Publications
CosMx SMI on the cover of Immunity supporting discoveries in the study of rheumatoid arthritis.
CosMx SMI is featured on the cover of Immunity, supporting discoveries in rheumatoid arthritis research. This groundbreaking study by MacDonald et al., from the Research into Inflammatory Arthritis Centre Versus Arthritis (RACE), Glasgow, UK, used high-fidelity spatial transcriptomics with CosMx SMI. The team mapped distinct dendritic cell clusters to specific synovial niches, revealing unique functions and unlocking promising therapeutic directions.The study used spatial single-cell analysis to advance our understanding of tissue-niche localization in autoimmune diseases.
CellScape image on the cover of Microscopy Today
Read how true quantitative spatial phenotyping starts with superior data collection in our recent Microscopy Today article. The CellScape platform, showcased on the cover of Microscopy Today, utilizes automated cyclic multiplex immunofluorescence technology allows for precise, high-resolution imaging of tissue samples while preserving their structural integrity.
Highlighted in the article are key innovative features of CellScape Precise Spatial Proteomics, including:
- Whole-Slide Imaging Chamber (WSIC)
- Filtered Photobleaching
- Multi-Exposure HDR Imaging
These advancements deliver unparalleled spatial and molecular insights. When paired with flexible VistaPlex™ assay kits, the CellScape platform empowers researchers to conduct iterative, hypothesis-driven investigations, accelerating discoveries in immune profiling, tumor microenvironments, and beyond.
Dive into the full Microscopy Today feature to explore the technology and its transformative potential.
Bruker Spatial Biology Around the World
Global Milestones and Exciting Updates
Our Customer Experience Lab in Amsterdam is now fully equipped with the CellScape Precise Spatial Proteomics Platform, allowing EU customers to gain hands-on experience with the CellScape platform joining the nCounter Analysis System, GeoMx DSP, and CosMx SMI systems.
Tips, Tricks, and Resources
New Interactive CellScape Precise Spatial Proteomics Datasets
Explore stunning multiplexed immunofluorescence images of various specimens and uncover the stories they tell. From pinpointing immune cell interactions to mapping tissue architecture, this tool makes it easy to visualize our CellScape platform’s spatial data. These incredible images are created using our EpicIF™ technology and VistaPlex assays on our CellScape platform—designed to bring your research to life and make groundbreaking discoveries possible.
In Case You Missed It
More than 500 people gathered in Berlin last December 12th and 13th for the inaugural meeting of the European Society for Spatial Biology and we were thrilled to be a part of it. During those 2 days, we engaged with an interdisciplinary audience from various fields of life science from pathologists and neuroscientists to tumor immunologists and data analysts.
Find Bruker Spatial Biology on Bluesky
Stay connected with us on Bluesky! We’ve officially launched our account for Bruker Spatial Biology, and we’d love for you to follow along. Stay up-to-date with the latest innovations, insights, and news in spatial biology. Join the conversation and engage with our growing community—follow us today at @brukerspatial!
At Bruker Spatial Biology, we are dedicated to advancing science through innovation, collaboration, and unmatched flexibility. Follow along for more updates, resources, and opportunities to transform your research.