Leverage High-Resolution MERFISH Spatial Profiling Technology
The MERSCOPE platform utilizes MERFISH (Multiplex Error-Robust Fluorescence in situ hybridization) spatial profiling technology, which enables highly multiplexed single-molecule imaging for quantification and sensitive detection of thousands of transcripts. We offer both custom panels and a suite of pre-designed MERSCOPE panels targeted for neuroscience, oncology, and IO applications.
You provide the tissue blocks and your targets of interest, and our services team will complete panel procurement, sample preparation, and slide processing on the MERSCOPE instrument.
Spatial Expertise
Our expertise in histology and FISH allows us to add the MERSCOPE workflow to our Multiomics Services lab. Our dedicated staff optimizes the workflow for the most efficient turnaround times for each project.
Easily Access Data Analysis
Access your data in the MERSCOPE® Vizualizer Software and interactively view the output of your experiment, including detected transcripts, segmented cell boundaries, and high-resolution images.
Powerful Spatial RNA Data
The MERSCOPE platform features high sensitivity and spatial resolution. Leverage our high-plex custom panel design service to get the data you need for your unique research.
Comprehensive Portfolio
We offer a carefully curated mix of spatial and single-cell analysis technologies that complement one another. Ask about how our comprehensive suite of services can provide powerful insights for your study.
How Our Service Works
Send Us Your Samples
The MERSCOPE platform is suitable for FFPE tissue blocks. Send us your tissue sample blocks and we will process them for you.
We Do the Work
We take care of designing and ordering your custom panels. After we receive your samples and the detection reagents, we get to work immediately.
We Deliver Your Data
Our scientists share your data with you and equip you with access to the MERSCOPE Vizualizer Software for in-depth analysis.
MERSCOPE RNA Spatial Imaging Services Workflow
Single molecule FISH (smFISH) technology uses fluorescently tagged oligonucleotides to label individual RNA transcripts, enabling precise quantification of gene expression at the single-cell level. MERFISH expands smFISH by adding combinatorial labeling, sequential imaging, and error-robust barcoding to increase the multiplexing capacity, allowing for the simultaneous detection of up to a thousand genes and to spatially localize transcripts to map gene expression across whole tissues.
Your Complete Spatial Transcriptomic Solution
Used together, our MERSCOPE and CosMx™ Spatial Molecular Imaging Service and CellScape™ Precise Spatial Proteomics Service provide powerful ways to analyze spatial transcriptomic data. GeoMx is designed to analyze your tissues. MERSCOPE can provide spatial transcriptomic output for up to 1,000 RNA sequences, while CosMx and CellScape offer more targeted image-based spatial proteomics with single-cell resolution.
With our complementary spatial transcriptomic services, you can use MERSCOPE to look at different gene expression and orthogonally validate your findings with predesigned protein panels using CosMx or CellScape.
Pre-designed Panels Available
Pre-designed panels can take the guess work out of your assay design. Mouse Pan Neuro and Human Pan Cancer, Immuno-Oncology and Liver Tumor Panels are currently available, and additional panels are coming soon. These pre-designed panels provide expertly curated lists of biologically relevant genes to enable cell typing and cellular function interrogation. The panels represent the fastest path to results and can be cost effective options for those just starting out with MERFISH technology.
For mouse neuroscience application, choose the ready-to-use PanNeuro 500-gene panel to identify and subtype cells in the mouse brain. The PanNeuro cell type mouse panel detects spatial gene expression in the mouse brain.
- Identify major cell types in the mouse brain, including neurons, immune cells, vascular cells, astrocytes, oligodendrocytes, peripheral glial cells, and microglia
- Explore funcitonal role of different cell subtypes
- Resolve neuronal and non-neuronal cell subtypes
- Use the predesigned panel across the entire brain region
Investigate the features of cellular interactions in teh tumor microenvironment and unravel the complex heterogeneity in tumors.
- Explore cancer signlaing
- Characterize tumor behavior
- Investigate interactions between tumor, immune, and stromal cells across human cancers
- Comapitble across a variety of human cancers
Targeting the immune response to cancer, this panel enables exploration of immune system interactions as well as responses to potential therapeutics.
- Identify major immune cells and subtypes
- Profile immune checkpoint effectors to enable the characterization of immune-cancer interplay
- Compatible across human cancers including breast, lung, liver, prostate, colon, melanoma, ovarian, and brain
Broad Sample Types and Custom Options
The custom panel design capability of the MERSCOPE platform makes this technology ideal for any species or tissue type. Whether your list of genes is narrow or extensive, custom panels can be designed to answer questions specific to your research area and sample type. Send us your custom gene list (select 140-gene, or 300-gene, or 500-gene custom options) and we can design your MERFISH panel for our MERSCOPE spatial imaging services.