CosMx® Human Whole Transcriptome Brain Dataset
This dataset demonstrates the power of the CosMx® SMI in characterizing the complex architecture of the human brain. Utilizing the CosMx Human Whole Transcriptome Panel, we analyzed normal hippocampus tissue from a 63 year old Caucasian male donor with a clinical history of cardiovascular conditions including CAD and hypertension. By applying this high plex assay to FFPE tissue, we captured the entire protein encoding transcriptome at true single cell subcellular resolution. By visualizing the whole transcriptome within this critical brain region, researchers can uncover subtle molecular changes and spatial relationships that define healthy aging or early pathological shifts, providing a foundation for uncharted neurological discoveries.
The CosMx® SMI and decoder probes are not offered and/or delivered to the Federal Republic of Germany for use in the Federal Republic of Germany for the detection of cellular RNA, messenger RNA, microRNA, ribosomal RNA and any combinations thereof in a method used in fluorescence in situ hybridization for detecting a plurality of analytes in a sample without the consent of the President and Fellows of Harvard College (Harvard Corporation) as owner of the German part of EP 2 794 928 B1. The use for the detection of cellular RNA, messenger RNA, microRNA, ribosomal RNA and any combinations thereof is prohibited without the consent of the President and Fellows of Harvard College (Harvard Corporation).
*defined-by: (transcripts per plex per cell) / (negatives per plex per cell)
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Dataset Overview
To showcase the CosMx SMI’s Whole Transcriptome capabilities,
view the UMAP and tissue image below.
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Technology Publication:
High-Plex Multiomic Analysis in FFPE Tissue at Single-Cellular and Subcellular Resolution by Spatial Molecular Imaging
