GeoMx Neural Proteome Atlas (NPA)

The largest spatial antibody-based biomarker panel for neuroscience

The GeoMx® Neural Proteome Atlas (NPA) delivers targeted, high-plex protein profiling optimized for neuroscience research. GeoMx NPA empowers researchers to comprehensively map neuronal, glial, and synaptic protein signatures directly in brain and nervous system tissues, without compromising spatial context.

Whether you’re uncovering mechanisms of disease such as Alzheimer’s, Parkinson’s, or Huntington’s, or revealing activation states, GeoMx NPA provides the depth, specificity, and reproducibility to move discoveries forward.

How it Works

01:

Comprehensive Neural Coverage

Profile neuronal, glial, and synaptic pathways with the largest antibody-based spatial assay for neuroscience.

02:

Understand Key Molecular Mechanisms

Interrogate 59 post-translational modifications (PTMs) critical to neural signaling and pathology. Reveal phosphorylation, acetylation, and ubiquitination changes driving neurodegeneration and synaptic plasticity.

03:

Interpret Complex Neural Biology

Explore proteins mapped to key neural processes and diseases, including neurogenesis, neuroinflammation, and neurodegeneration. Each target is curated to relevant signaling pathways for rapid biological interpretation.

04:

Multiomic-Integration with GeoMx WTA

Correlate protein and RNA expression in the same spatial regions with the GeoMx Whole Transcriptome Atlas (WTA). Gain a complete view of neural biology from transcription to function.

05:

Resolve Protein Expression at Single-Cell Resolution

Quantify protein abundance at single-cell resolution within defined neural and glial populations. Preserve spatial context to reveal cell-type-specific biology in complex brain tissue.

06:

Customize with Additional Antibodies

Expand your assay with up to 40 user-selected targets using the GeoMx Protein Barcoding Service. Easily tailor GeoMx NPA to explore novel or pathway-specific neuroscience targets.