CellScape™ PSP Knowledge Base: CellScape PSP System

The CellScape PSP platform is an advanced spatial biology system designed for high-plex, quantitative spatial phenotyping at single-cell and subcellular resolution within formalin-fixed paraffin-embedded (FFPE) or fresh frozen (FF) samples. It integrates the highest-resolution spatial imaging, automated fluidics, and flexible assay chemistry to facilitate comprehensive spatial proteomics studies.

The CellScape PSP platform is ideal for studies requiring spatially resolved protein data with best-in-class resolution, including research in oncology, immunology, neuroscience, and infectious disease. Researchers use the CellScape PSP platform to analyze tissue architecture, cellular interactions, and disease microenvironments with subcellular precision. Its unmatched flexibility and modularity are well suited for custom assay development, and its straightforward and simple workflow make it highly valuable for biomarker validation following discovery studies.

The CellScape™ PSP platform is compatible with tissue samples from any species and supports both fresh frozen (FF) and formalin-fixed paraffin-embedded (FFPE) formats. It uses a standard 75 mm x 25 mm glass microscope slide (frosted or unfrosted), making it easy to incorporate into existing workflows. With the Whole Slide Imaging Chamber (WSIC) technology, each slide is converted into a microfluidic device—enabling uniform reagent delivery and high-plex staining across the entire tissue section.

The CellScape PSP platform facilitates whole-slide imaging with an available imaging area of up to 710mm², facilitating the use of large tissue sections, tissue arrays, and tissue mircoarrays (TMAs).

Yes, the CellScape PSP platform supports whole-slide imaging.

Thanks to the gentle EpicIF workflow and filtered photobleaching, we’ve seen minimal issues with reduced marker detection in later staining rounds. To address any concerns about steric hindrance or epitope instability, we recommend placing “high-risk” markers in the earliest cycles.

The CellScape PSP platform can automate the sequential staining and imaging of up to four slides in a single run.

Yes, the CellScape PSP is offered through Canopy Multiomics Services. This service allows customers to outsource the entire workflow, including sample submission and prep, automated staining, high-plex imaging, and cell phenotyping. For more details or to initiate a project, you can visit our dedicated CellScape platform services page.

From sample input to data output, Bruker Spatial Biology offers world-class customer support to our customers. Our technical and customer support teams are trained to provide local and remote support from project conception to completion.

The CellScape PSP platform is designed and manufactured by Bruker Corporation, and it is distributed globally via Bruker Spatial Biology.

Yes, contact your local representative here to generate quantitative spatial phenotyping data from the CellScape platform via our Technology Access Program (TAP).