Bruker Spatial Biology Product Roadmap for 2026
Introducing CellScape™ XR, the Highest Performing Spatial Proteomics Ecosystem Delivering Best-in-Class Data Fidelity, Robustness and Flexibility
CellScape XR is the next generation of Bruker’s precise spatial proteomics platform. CellScape XR combines major advancements across the instrumentation, software, and the assay ecosystem to deliver best-in-class data quality, dramatically expand available markers, more than double throughput, with further improved robustness and flexibility. This includes improvements in optics and imaging chamber design, which combined with EpicIF™ technology, enables rapid whole-slide signal removal between staining cycles within seconds. The launch also includes expanded VistaPlex™ multiplex assay kits, building on hardware improvements that enable use of a broader range of fluorophore conjugated antibodies, and PowerOMX™ data engine for improved data processing. The significantly expanded menu of VistaPlex assay kits is comprised of primary fluorescently labelled antibodies for robust assay performance. With Bruker’s proprietary EpicIF technology, fluorescence signal from any organic fluorophore can be removed, enabling users to customize VistaPlex panels with a wide range of directly conjugated antibodies. As an add-on to the VistaPlex kits, Bruker will offer a new universal antibody labeling capability, VistaFlex™, developed in collaboration with Proteintech® Group, enabling use of virtually any IHC-validated unlabeled antibody on the market without the need for antibody stripping, thus broadening assay design freedom and opening access to a wider range of protein targets and application‑specific antibodies.
Pre‑orders are open now, and commercial shipments of CellScape XR are expected this summer.
High Precision, Multiplexed Direct Visualization of the 3D Genome with PaintScape™
PaintScape is a first and only high precision platform enabling multiplexed, direct visualization of the 3D genome in situ in single cells. PaintScape enables the unprecedented study of genome organization and structure, allowing researchers to visualize chromosomal organization and investigate how spatial genome structural variations influence gene dysregulation and disease biology. At AGBT 2026, Bruker presented first-of-its-kind 3D genome visualization on both cell lines and intact fresh frozen (FF) tissue using the PainScape platform. In addition, Bruker will launch two new panels for the PaintScape platform, including the ChromoPaint™ HuCL PanChromo MPX panel, a 419-plex panel designed for genome wide in situ visualization of chromosomal organization in human cell lines. Lastly, Bruker announced the OncoPaint™ Oncogenic Pathway Panel that will be available later this year, a 1000+-plex modular panel designed to combine genome wide chromosome painting with painting of select cancer pathway associated gene regions in increased genomic resolution.
Pre-orders are open now, and commercial shipments of the PaintScape platform are expected to begin this spring.
CosMx® SMI Extends Complete Spatial Biology Approach to miRNA, TCR, and Mouse Whole Transcriptome
Bruker’s CosMx Spatial Molecular Imager (SMI) delivers the most complete single-cell and subcellular spatial transcriptomic view of human biology through multiomic imaging of the whole transcriptome (WTX) plus 64+ proteins from a single FFPE or FF tissue section. Bruker now extends their complete biology approach to mouse research by announcing development of the CosMx Mouse Whole Transcriptome (WTX) assay. The mouse WTX assay will be available for both FFPE and FF tissues with early access through Bruker’s Technology Access Program this spring and full commercial availability later this year. Bruker also unveiled plans for commercial high-plex spatial miRNA and T-Cell Receptor (TCR) assays at subcellular resolution. The new miRNA assay will enable researchers to jointly interrogate mRNA, protein, and miRNA from the same cell, delivering a more complete multiomic view of gene regulation, post-transcriptional control, and cell state transitions. The TCR assay for the study of variable–diversity–joining mRNA expression will provide a new layer of in-depth immune biology in addition to whole transcriptome imaging.
AtoMx® SIP Leverages Complete Biology Layers for Image-First Experience, AI-Ready Data, and 3D Cell Segmentation
Bruker’s AtoMx Spatial Informatics Platform (SIP), designed to accelerate study-level insights from CosMx SMI data, now introduces a spatial discovery mode for rapid image-based exploration of subcellular and single-cell whole transcriptome data. This new experience pre-calculates spatial insights as well as prepares data exports for conversational large language models (LLM). Applying LLMs to the comprehensive data of CosMx SMI results in richer and higher quality LLM outputs than would be possible with any other commercial spatial assay and platform, giving researchers the most complete interactive experience for biological understanding. Bruker also introduced 3D AI cell segmentation models to AtoMx SIP, extending their best-in-class definition of single-cell boundaries for accurate RNA transcript assignment in space. This advancement addresses long-standing limitations of other platforms and cell segmentation algorithms that do not account for biologically overlapping cells in tissue sections.
GeoMx® Discovery Proteome Atlas Showcases Unmatched Spatial Biomarker Discovery at Scale with Whole Transcriptome and 1200+ Protein Targets
Bruker’s GeoMx Digital Spatial Profiler (DSP) enables large-cohort interrogation of the whole transcriptome and the Discovery Proteome Atlas (DPA), a spatial assay profiling more than 1,200 protein targets. At AGBT 2026, researchers presented applications ranging from oncology to neuroscience, demonstrating how GeoMx DSP opens the possibilities for spatial biomarker discovery at scale. Bruker additionally introduced a cross-platform GeoMx DPA and CellScape XR workflow from the same tissue section that presents an unprecedented opportunity for spatial protein biomarker discovery to subsequent validation and translational studies.
nCounter® Extends Leadership in Gene Expression Analysis with New Multiomics Capabilities
nCounter is now multiomic! With the power to measure RNA and protein from the same sample on a single platform and within one streamlined workflow, the nCounter Analysis System is more capable than ever. To complement this advancement, Bruker Spatial Biology has introduced the nCounter Data Analysis Pipeline—a user‑friendly desktop solution designed for rapid, publication‑ready insights. From raw data to high‑quality outputs in minutes, it brings simplicity and speed to multiomic data analysis.
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