CosMx Whole Transcriptome Assay
Reveal complete tissue biology with whole transcriptome subcellular spatial imaging in human and mouse samples
CosMx® Whole Transcriptome (WTX) assays are designed to measure the full protein-coding transcriptome with single-cell and subcellular spatial resolution in intact FFPE and fresh frozen tissue. By combining transcriptome-scale coverage with high fidelity and high-sensitivity spatial imaging, WTX enables complete pathway-level spatial insights.
Why CosMx WTX panel?
- Direct and complete projection of pathway biology in space
Move beyond inferred biology based on cell types with direct spatial measurement of functional biological pathways across the tissue. - Best-in-class sensitivity and genomic breadth designed for FFPE and fresh frozen tissue
Enable robust gene discovery, comprehensive tissue phenotyping, and spatial analysis from FFPE and fresh frozen tissue section. - Disruptive discoveries at subcellular resolution
Obtain ‘Molecular fingerprint’ from every patient sample.
CosMx Human WTX data is already the industry standard, foundationally supporting the $50M Noetik-GSK deal and massive datasets like Arutha Kulasinghe’s NSCLC study.
And we are expanding the WTX portfolio, with
Mouse WTX currently available for pre-order NOW!!!
The CosMx® SMI and decoder probes are not offered and/or delivered to the Federal Republic of Germany for use in the Federal Republic of Germany for the detection of cellular RNA, messenger RNA, microRNA, ribosomal RNA and any combinations thereof in a method used in fluorescence in situ hybridization for detecting a plurality of analytes in a sample without the consent of the President and Fellows of Harvard College (Harvard Corporation) as owner of the German part of EP 2 794 928 B1. The use for the detection of cellular RNA, messenger RNA, microRNA, ribosomal RNA and any combinations thereof is prohibited without the consent of the President and Fellows of Harvard College (Harvard Corporation).
CosMx Human WTX Resources
Featured Publication:
In this peer-reviewed publication in the Journal of Clinical Investigation, researchers used the CosMx Human WTX assay to directly map the spatial molecular architecture of immune exclusion, identify key biological programs, and localize regulators that shape the tumor microenvironment.
Complete coverage of pathways: Human Colon Whole Transcriptome Imaging
Project the entire tissue biology at the RNA pathway level to generate a “molecular fingerprint” of each tissue sample and shift from inferring biology to direct, functional measurements.
Uncover every tissue’s hidden story: Human Pancreas Whole Transcriptome Imaging
Unbiased whole-transcriptome imaging of human pancreas with CosMx SMI enabled comprehensive detection of cellular diversity, including rare cell populations that are often missed by targeted and single cell approaches.
CosMx Mouse WTX Resources
AACR 2026 Posters
The CosMx Mouse WTX Assay enabled whole-transcriptome imaging of mouse embryos to map cellular organization across both space and time. By combining cell typing and spatial niche analysis across multiple developmental stages, researchers resolved organ formation: including retina, liver, heart, and gonads, with high spatial resolution. This approach gives a holistic view of embryonic development, revealing how localized gene expression drives tissue and organ formation at unprecedented resolution.
The CosMx Mouse WTX assay applied to mouse CRC liver metastasis samples, enabled comprehensive spatial profiling indicating stromal remodeling as a key early feature of treatment response.
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