CosMx® Human Whole Transcriptome Kidney Dataset
This dataset demonstrates the power of the CosMx® SMI in characterizing clinical Renal Clear Cell Carcinoma (RCC) samples. Utilizing the CosMx Human Whole Transcriptome Panel, we analyzed a G3, Stage III (T3aN0M0) primary kidney tumor from a 71-year-old Caucasian male donor. By applying this high-plex assay to FFPE tissue, we captured the entire protein-encoding transcriptome—over 18,000 genes—at the highest subcellular resolution. By visualizing the distribution of the whole transcriptome in these complex samples, researchers can identify unique molecular signatures and cellular
The CosMx® SMI and decoder probes are not offered and/or delivered to the Federal Republic of Germany for use in the Federal Republic of Germany for the detection of cellular RNA, messenger RNA, microRNA, ribosomal RNA and any combinations thereof in a method used in fluorescence in situ hybridization for detecting a plurality of analytes in a sample without the consent of the President and Fellows of Harvard College (Harvard Corporation) as owner of the German part of EP 2 794 928 B1. The use for the detection of cellular RNA, messenger RNA, microRNA, ribosomal RNA and any combinations thereof is prohibited without the consent of the President and Fellows of Harvard College (Harvard Corporation).
*defined-by: (transcripts per plex per cell) / (negatives per plex per cell)
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Dataset Overview
Whole transcriptome spatial data from kidney tissue. The immunofluorescence image below shows CD45 in red, DNA in blue, CD68 in yellow, Membrane in gray, PanCK in green.
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Technology Publication:
High-Plex Multiomic Analysis in FFPE Tissue at Single-Cellular and Subcellular Resolution by Spatial Molecular Imaging
