Bruker Spatial Biology Blog
Digital Spatial Profiling GeoMx DSP Spatial Biology Spatial Transcriptomics
GeoMx® DSP: What Surprised This Early Adopter Most
During her post doc years, Trieu My Van explored the effects of immuno check point blockade in melanoma patients, comparing samples from metastatic uveal and cutaneous melanoma tissues at the…
Neuroscience
A Strategic Attack Against Neurological Diseases
Neurological diseases are often multifactorial, brought on by a genetic and environmental tug-of-war and resulting in multifaceted clinical presentations. Such etiological complexity has hindered treatment progress and has necessitated well-thought-out…
Clinical Research Digital Spatial Profiling GeoMx DSP Spatial Biology Spatial Transcriptomics
How the Field of Immuno-Oncology is Changing Fast
Immuno-oncology, also known as cancer immunotherapy, is a treatment that harnesses the power of our immune system to fight cancer. The selective efficacy of immunotherapies continues to provide impetus for…
Autoimmunity
Q&A with Dr. Maureen McGargill, PhD: The Immune System’s Fine Line Between Health and Harm
Dr. McGargill earned her PhD at the University of Minnesota in Dr. Kristin Hogquist’s lab. There she studied T cell development, focusing on how autoreactive T cells are deleted during…
Oncology
miRNA Profiling in Malignant Melanoma: Making “Australia’s National Cancer” Obsolete.
Australia is a sun-worshipping country, the world capital for beautiful beaches, athletic surfers, cute marsupials, and the occasional weird-looking animal. But it is also the capital for something less pleasant:…
Neuroscience
A Systematic Evaluation of Immune Response and Plaque Microenvironment Variation in Alzheimer’s Disease
Alzheimer’s disease (AD) – the most prevalent form of dementia – is associated with defining histopathological features that include amyloid-beta (Aβ) plaque deposition and tau protein aggregation, accompanied by synaptic…
Oncology
Mapping the miRNA-mRNA Interactome in Multiple System Atrophy
A rapidly developing and fatal neurodegenerative disorder, MSA is frequently misdiagnosed or undetected until later stages due to its systemic nature, undefined etiopathogenesis, and multifaceted clinical presentation. In an attempt…
Oncology
Q&A with Dr. Lisa Butterfield, PhD: Cancer Vaccines & Adoptive Cell Transfer
Dr. Lisa Butterfield, PhD recently joined the Parker Institute for Cancer Immunotherapy as Vice President focusing on cell therapies while she continues her independent cancer vaccine research as an Adjunct…
Autoimmunity
Identifying Signaling Pathways and Biomarkers in Autoimmune Diseases
As efforts in developing targeted therapies for autoimmune disease are rapidly advancing in basic research, scientists aim to validate immunology-relevant signaling pathways and uncover new intracellular molecules as potential drug…
Neuroscience
New Biology-Driven Drug Discoveries Needed for Treating of Alzheimer’s
Alzheimer’s disease (AD) is a slowly progressing neurodegenerative disorder that affects millions of people worldwide, leaving behind an immense psychological, emotional, and financial burden on patients, caregivers, and healthcare systems.…
Autoimmunity Immunology
Q&A with Dr. Oliver Brain: Unintended Consequences Create a Unique Opportunity to Study Inflammatory Bowel Disease.
Oliver Brain, MRCP, PhD, is a principal investigator at the University of Oxford, Nuffield Department of Clinical Medicine, and a recent winner of an nCounter® Autoimmune Profiling Panel through a…
Autoimmunity
Q&A with Dr. Salla Keskitalo: Challenges and Opportunities in Studying Rare and Ultra-rare Autoimmune Diseases
Dr. Salla Keskitalo is a Senior Research Scientist at the University of Helsinki and a recent winner of NanoString’s Autoimmunity Grant Program. She made time to speak with us about…