Bruker Spatial Biology Blog
Category: CosMx SMI
CosMx SMI
Accurate Cell Segmentation: The Critical Foundation of Spatial Biology
Authors: Kalyan Chavda, Lidan Wu, Aster Wardhani Spatial biology has entered the era of single-cell and subcellular resolution and generating high-dimensional molecular data is no longer the challenge. Interpreting it…
CosMx SMI
Key Considerations in High-Fidelity Spatial Transcriptomics with CosMx® SMI
Authors: Kalyan Chavda, Christine Kang, Martin Shelton, Prajan Divakar As spatial biology transitions into a foundational tool in scientific research, Core Lab Managers and Principal Investigators are faced with an…
CosMx SMI
How CosMx SMI Enables Next-Generation Spatially Resolved Cell Assays with Subcellular Resolution
The ability to simultaneously map morphology, RNA, and protein at the subcellular level is the new frontier in cell biology. While the CosMx® Spatial Molecular Imager (SMI) is renowned for…
CosMx SMI
Why Transcriptomics Matters: Understanding the Value of High-Resolution Spatial Molecular Imaging
As spatial biology reshapes the future of biomedical research, spatial transcriptomics has emerged as one of the most powerful tools for revealing complex tissue biology. Technologies like the CosMx® Spatial…
CosMx SMI
Tips to optimize the CosMx Multiomics sample prep for fragile tissues
Tips to optimize the CosMx Multiomics sample prep for fragile tissues The CosMx multiomics platform enables sequential protein and RNA analysis on the same tissue sample, combining a 64-plex protein…
CosMx SMI
The CosMx SMI 2.0: Unmatched advances in single-cell spatial transcriptomics
Explore the CosMx SMI 2.0: Higher RNA sensitivity, whole transcriptome imaging, and faster high fidelity, subcellular spatial transcriptomics.
CosMx SMI
Tips to optimize sample prep for highly autofluorescent samples on CosMx® SMI
The CosMx® Spatial Molecular Imager (SMI) instrument performs fluorescent imaging to read out in-situ hybridized fluorescent reporters which uniquely identify RNA transcripts. The presence of tissue autofluorescence background may reduce…
CosMx SMI
Moving Beyond scRNA-seq: The Power of CosMx Whole Transcriptome
Compare CosMx SMI versus scRNA-seq and see how spatial transcriptomics reveals more biology in intact tissue and with subcellular resolution.
CosMx SMI
Revealing Spatial Biology at Whole-Transcriptome Scale: Introducing the CosMx® Human Whole Transcriptome Panel
Learn how CosMx WTX brings whole-transcriptome coverage to every cell in FFPE tissues, uncovering truly groundbreaking spatial biology.
CosMx SMI
Tips when performing CosMx® data analysis with AtoMx SIP
Single-cell spatial biology opens doors to unprecedented scientific questions requiring the development of new computational workflows and approaches to analyze and interpret data. Whether you are new to single-cell spatial…
CosMx SMI
Tips when Generating Single-Cell Spatial Data: Post Run H&E and Antibody Staining
We are excited to share the third installment of tips for successful CosMx® SMI single-cell spatial runs at 1000-plex. Our first installment of tips focused on data by tissue and…
CosMx SMI
Tips When Generating Single-Cell Spatial Data: Sample Selection
We are excited to share the second installment of tips for successful CosMx® SMI single-cell spatial runs at 1000-plex. Our first installment of tips focused on data by tissue and…