Bruker Spatial Biology Blog

The function of biological systems depends on the spatial organization of their cells. Over the past decade, innovative technologies have emerged that can spatially localize and quantify gene expression of…

Immunofluorescence staining is an incredibly powerful yet simple imaging technique that optically detects the localization, distribution, and abundance of proteins at a cellular and intracellular level using fluorescent tags on…

Understanding how gene expression orchestrates cellular organization within tissues is essential to gain mechanistic insights into development and disease. Spatial transcriptomics allows capturing of transcriptional activity along with positional context…

The emergence of spatial transcriptomics, with its ability to generate highly detailed maps of gene expression with spatial context, is revolutionizing biomedical research, particularly in developmental biology, cancer, immunology, and…

In the field of medical imaging, the region of interest (commonly abbreviated as ROI) is an area within an image that is selected for a particular purpose, including defining boundaries…

Spatial biology is the new frontier of molecular biology that has revolutionized the study of gene and protein expression. Until recently, expression patterns were obtained via bulk sequencing or single-cell…

What is Spatial Biology? The rapidly evolving field of spatial biology investigates the spatial location and organization of gene expression in situ within each cell and structure of a given tissue sample.…

Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease affecting people who have suffered repeated concussions and traumatic brain injuries (TBI). CTE was first described in 1928 by Dr. Harrison…

What is CAR-T cell therapy? In the fight against cancer, immunotherapies that enlist and strengthen the power of a patient’s immune system to attack tumor cells have revolutionized treatment paradigms.…

What is Multiple Sclerosis? In 1868, a German physician Leopold Ordenstein and his mentor Jean-Martin Charcot, published a work that fundamentally changed our understanding of the disease Multiple Sclerosis¹. For…

The idiom “to lose one’s nerves” is literally true when it comes to neurodegenerative disorders. These disorders are characterized by the progressive loss of disease-specific neural populations in the brain…

Alzheimer's disease pathology: a short sentence loaded with fear, confusion, and incredulity. The word “Alzheimer’s” first appeared in a German psychiatry handbook called “General Psychiatry” on July 15, 1910. This…