Bruker Spatial Biology Blog
CosMx SMI
How CosMx SMI Enables Next-Generation Spatially Resolved Cell Assays with Subcellular Resolution
The ability to simultaneously map morphology, RNA, and protein at the subcellular level is the new frontier in cell biology. While the CosMx® Spatial Molecular Imager (SMI) is renowned for…
Miscellaneous
January 2025 Newsletter
With AGBT 2025 right around the corner and exciting announcements from Bruker Spatial Biology coming, we’re here to bring you the latest updates, innovations, and resources in spatial biology. Upcoming…
CosMx SMI
Why Transcriptomics Matters: Understanding the Value of High-Resolution Spatial Molecular Imaging
As spatial biology reshapes the future of biomedical research, spatial transcriptomics has emerged as one of the most powerful tools for revealing complex tissue biology. Technologies like the CosMx® Spatial…
CosMx SMI
Tips to optimize the CosMx Multiomics sample prep for fragile tissues
Tips to optimize the CosMx Multiomics sample prep for fragile tissues The CosMx multiomics platform enables sequential protein and RNA analysis on the same tissue sample, combining a 64-plex protein…
Miscellaneous
Understanding Bulk Multiomics: A Technical Introduction
Miscellaneous
October 2025 Newsletter
This month brings exciting milestones across our portfolio. Washington University School of Medicine’s Orr Lab has been named a Bruker Spatial Biology Center of Excellence, marking a new chapter in…
CosMx SMI
The CosMx SMI 2.0: Unmatched advances in single-cell spatial transcriptomics
Explore the CosMx SMI 2.0: Higher RNA sensitivity, whole transcriptome imaging, and faster high fidelity, subcellular spatial transcriptomics.
Miscellaneous
June 2025 Newsletter
We're excited to share a major step forward: the nCounter® platform is now enabling simplified RNA and protein analysis in a single workflow. Dive into our newest capabilities for bulk multiomics,…
Spatial Biology
Optimizing Multiplex Immunofluorescence Assays on the CellScape Platform
Over the last few years, more and more researchers have embraced multiplex immunofluorescence (mIF), and for good reason. The ability to visualize many biomarkers in a single tissue section can…
Miscellaneous
Spatial Biology Takes Center Stage at AACR 2025
This year’s American Association for Cancer Research (AACR) Annual Meeting highlighted the power of spatial and multiomics technologies to illuminate the cellular and molecular complexity of cancer. Across all five…
CosMx SMI
Tips to optimize sample prep for highly autofluorescent samples on CosMx® SMI
The CosMx® Spatial Molecular Imager (SMI) instrument performs fluorescent imaging to read out in-situ hybridized fluorescent reporters which uniquely identify RNA transcripts. The presence of tissue autofluorescence background may reduce…
CosMx SMI
Moving Beyond scRNA-seq: The Power of CosMx Whole Transcriptome
Compare CosMx SMI versus scRNA-seq and see how spatial transcriptomics reveals more biology in intact tissue and with subcellular resolution.