Bruker Spatial Biology Blog
CosMx SMI
Common questions in molecular biology: What is the importance of cell interactions?
Can you imagine if a cell could send an email? Or put in a work request? Think of it: Dear Immune System, I am infected by a virus. Please send…
CosMx SMI
Common questions in molecular biology: What are types of cell-cell interactions?
Much like bees or ants, cells are inherently social. Also like various hive-based insects, the social nature of the interactions are important for dictating function and well being of the…
CosMx SMI
Common questions in molecular biology: Why do we need biomarkers?
What does it mean to be healthy? If you go in for a regular wellness appointment at the doctor’s office, how does the doctor assess if you are healthy? Wellness…
CosMx SMI
Common questions in molecular biology: What can biomarkers tell us?
As we go about our day, we are surrounded by indicators. Our clocks tell us the time. Ovens will reveal their current temperatures and alert us when they’ve reached their…
CosMx SMI Spatial Transcriptomics
Common questions in molecular biology: What are the most common biomarkers?
If you stopped someone on the street and asked them to give you an example of a common biomarker, you will more than likely be met with silence. However, if…
CosMx SMI
Common questions in molecular biology: What is an example of a biomarker?
It’s time for your yearly wellness visit with your doctor. It’s the same thing every year. They check your weight, blood pressure, oxygen saturation and pulse. Perhaps you have to…
CosMx SMI Multiomics Spatial Analysis
Unveiling the Inner Lives of Cells: A Spatial Look at Cell-Cell Interaction
Cells are the building blocks of all living things, from single-celled organisms such as bacteria to multi-celled organisms like whales. At the most basic level, though, all cells function in…
CosMx SMI Spatial Transcriptomics
A Spatial Twist on Biomarkers: Using Spatial Transcriptomics for Biomarker Discovery
Anyone who studies biology knows that living systems are highly complex, sophisticated entities, often containing redundant processes. Sorting out the mechanisms at play in any biological system is therefore aided…
Spatial Biology
Situating Single Cell RNA-seq in the Context of Multiomics
Cells, the building blocks of all life, are built from biological molecules such as proteins and RNA. Biological molecules perform all the functions of living cells, from DNA replication to…
CosMx SMI GeoMx DSP Spatial Biology
Single-Cell Spatial Surpasses Single-Cell Sequencing
Modern biology research is deeply interested in discovering the fundamental mechanics that operate within an organism of interest. Since the fundamental unit of all living organisms is the cell, it…
Spatial Biology
Morphology Markers 101: Enabling Spatial Multiomics
Remarkable advances in spatial multiomics have been made in the last several years, with companies like NanoString introducing automated instruments capable of imaging, quantifying, and localizing RNA and protein expression…
Oncology
What is Comparative Oncology and Why Has it Gone to the Dogs?
Deciding which model system to use to answer biological questions is a critical choice in research. Many human diseases occur naturally or can be reproduced in animals. Depending on the…